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As morbid as it may sound, from the moment you're born, each day is one day closer to death, a factual inevitability of life that befalls everyone. But the time you spend on Earth differs for everyone. Some live extraordinarily long lives, like the oldest woman in the world, Tomiko Itooka of Japan, who as of August 2024 is 116 years old (she replaced the previous oldest woman, Maria Branyas of Spain who died at 117 years old), while others have their lives cut far too short. Many of these lives are lost to disease.
The current life expectancy differs in each country but in the United States. According to the Congressional Budget Office, it is now said to be 78.7 years, although their projections differ from other agencies that have it slightly higher – the Census Bureau has a 2024 life expectancy of 79.9 years. Women also typically have a higher average life expectancy than men. (Also, read about the 12 biggest public health conspiracies of all time.)
To determine the disease that has taken the lives of death over four million people in just five years, 24/7 Tempo reviewed data on mortality rates for over 100 selected causes of death from the Centers for Disease Control and Prevention (CDC). Major causes of death were ranked based on the crude mortality rate – annual deaths per 100,000 Americans – from 2018 to June 1, 2024.
15. Parkinson's disease
- Mortality rate, 2018 to June 2024: 10.6 per 100,000 Americans
- Age-adjusted mortality rate: 8.6 per 100,000 people
- Total deaths: 244,732
14. Essential hypertension and hypertensive renal disease
- Mortality rate, 2018 to June 2024: 11.2 per 100,000 Americans
- Age-adjusted mortality rate: 9 per 100,000 people
- Total deaths: 260,349
13. Septicemia
- Mortality rate, 2018 to June 2024: 11.3 per 100,000 Americans
- Age-adjusted mortality rate: 9.1 per 100,000 people
- Total deaths: 261,209
12. Intentional self-harm (suicide)
- Mortality rate, 2018 to June 2024: 12.3 per 100,000 Americans
- Age-adjusted mortality rate: 11.9 per 100,000 people
- Total deaths: 285,949
If you or someone you know is in crisis, please call the 988 Suicide and Crisis Lifeline, which has trained listeners standing by and ready to help. Visit 988lifeline.org for crisis chat services or more information.
11. Influenza and pneumonia
- Mortality rate, 2018 to June 2024: 13.8 per 100,000 Americans
- Age-adjusted mortality rate: 11.2 per 100,000 people
- Total deaths: 319,844
10. Chronic liver disease and cirrhosis
- Mortality rate, 2018 to June 2024: 13.9 per 100,000 Americans
- Age-adjusted mortality rate: 11.8 per 100,000 people
- Total deaths: 323,019
9. Nephritis, nephrotic syndrome and nephrosis
- Mortality rate, 2018 to June 2024: 14.9 per 100,000 Americans
- Age-adjusted mortality rate: 12 per 100,000 people
- Total deaths: 345,974
8. Diabetes mellitus
- Mortality rate, 2018 to June 2024: 26.5 per 100,000 Americans
- Age-adjusted mortality rate: 21.2 per 100,000 people
- Total deaths: 612,908
7. Alzheimer's disease
- Mortality rate, 2018 to June 2024: 33.6 per 100,000 Americans
- Age-adjusted mortality rate: 27.3 per 100,000 people
- Total deaths: 779,432
6. Chronic lower respiratory diseases
- Mortality rate, 2018 to June 2024: 41.7 per 100,000 Americans
- Age-adjusted mortality rate: 33 per 100,000 people
- Total deaths: 966,849
5. Cerebrovascular diseases
- Mortality rate, 2018 to June 2024: 43.9 per 100,000 Americans
- Age-adjusted mortality rate: 35.5 per 100,000 people
- Total deaths: 1,017,850
4. COVID-19
- Mortality rate, 2018 to June 2024: 44 per 100,000 Americans
- Age-adjusted mortality rate: 35.6 per 100,000 people
- Total deaths: 1,019,651
3. Accidents (unintentional injuries)
- Mortality rate, 2018 to June 2024: 51.9 per 100,000 Americans
- Age-adjusted mortality rate: 48.8 per 100,000 people
- Total deaths: 1,201,506
2. Malignant neoplasms (cancer)
- Mortality rate, 2018 to June 2024: 167.4 per 100,000 Americans
- Age-adjusted mortality rate: 132.5 per 100,000 people
- Total deaths: 3,877,440
1. Diseases of heart
- Mortality rate, 2018 to June 2024: 188.5 per 100,000 Americans
- Age-adjusted mortality rate: 151.5 per 100,000 people
- Total deaths: 4,367,569