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The United States is often acknowledged for its higher spending in many areas compared to other nations, and health care is no exception. According to the Centers for Medicare and Medicaid Services, the U.S. spent more than 4.9 trillion in 2023, which amounts to about 14,570 per person, more than four times the average for other nations of wealth. Yet, the U.S. mortality rates are still high.
To determine the deadliest trends in U.S. mortality over the past five years, 24/7 Tempo reviewed data on mortality rates for over 100 selected causes of death from the Centers for Disease Control and Prevention (CDC). Major causes of death were ranked based on the crude mortality rate—annual deaths per 100,000 Americans—from 2018 to June 1, 2024. (Check out the 12 biggest public health conspiracies of all time.)
This post was updated May 15th, 2025 with recent statistics.
15. Parkinson's disease
- Mortality rate, 2018 to June 2024: 10.6 per 100,000 Americans
- Age-adjusted mortality rate: 8.6 per 100,000 people
- Total deaths: 244,732
14. Essential hypertension and hypertensive renal disease
- Mortality rate, 2018 to June 2024: 11.2 per 100,000 Americans
- Age-adjusted mortality rate: 9 per 100,000 people
- Total deaths: 260,349
13. Septicemia
- Mortality rate, 2018 to June 2024: 11.3 per 100,000 Americans
- Age-adjusted mortality rate: 9.1 per 100,000 people
- Total deaths: 261,209
12. Intentional self-harm (suicide)
- Mortality rate, 2018 to June 2024: 12.3 per 100,000 Americans
- Age-adjusted mortality rate: 11.9 per 100,000 people
- Total deaths: 285,949
If you or someone you know is in crisis, please call the 988 Suicide and Crisis Lifeline, which has trained listeners standing by and ready to help. Visit 988lifeline.org for crisis chat services or more information.
11. Influenza and pneumonia
- Mortality rate, 2018 to June 2024: 13.8 per 100,000 Americans
- Age-adjusted mortality rate: 11.2 per 100,000 people
- Total deaths: 319,844
10. Chronic liver disease and cirrhosis
- Mortality rate, 2018 to June 2024: 13.9 per 100,000 Americans
- Age-adjusted mortality rate: 11.8 per 100,000 people
- Total deaths: 323,019
9. Nephritis, nephrotic syndrome and nephrosis
- Mortality rate, 2018 to June 2024: 14.9 per 100,000 Americans
- Age-adjusted mortality rate: 12 per 100,000 people
- Total deaths: 345,974
8. Diabetes mellitus
- Mortality rate, 2018 to June 2024: 26.5 per 100,000 Americans
- Age-adjusted mortality rate: 21.2 per 100,000 people
- Total deaths: 612,908
7. Alzheimer's disease
- Mortality rate, 2018 to June 2024: 33.6 per 100,000 Americans
- Age-adjusted mortality rate: 27.3 per 100,000 people
- Total deaths: 779,432
6. Chronic lower respiratory diseases
- Mortality rate, 2018 to June 2024: 41.7 per 100,000 Americans
- Age-adjusted mortality rate: 33 per 100,000 people
- Total deaths: 966,849
5. Cerebrovascular diseases
- Mortality rate, 2018 to June 2024: 43.9 per 100,000 Americans
- Age-adjusted mortality rate: 35.5 per 100,000 people
- Total deaths: 1,017,850
4. COVID-19
- Mortality rate, 2018 to June 2024: 44 per 100,000 Americans
- Age-adjusted mortality rate: 35.6 per 100,000 people
- Total deaths: 1,019,651
3. Accidents (unintentional injuries)
- Mortality rate, 2018 to June 2024: 51.9 per 100,000 Americans
- Age-adjusted mortality rate: 48.8 per 100,000 people
- Total deaths: 1,201,506
2. Malignant neoplasms (cancer)
- Mortality rate, 2018 to June 2024: 167.4 per 100,000 Americans
- Age-adjusted mortality rate: 132.5 per 100,000 people
- Total deaths: 3,877,440
1. Diseases of heart
- Mortality rate, 2018 to June 2024: 188.5 per 100,000 Americans
- Age-adjusted mortality rate: 151.5 per 100,000 people
- Total deaths: 4,367,569
