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Mysterious Cold Cases That Have Baffled America for Decades

Mysterious Cold Cases That Have Baffled America for Decades

The Murder of Andrew and Abby Borden
Public Domain / Wikimedia Commons
The Villisca Ax Murders
Public Domain / Wikimedia Commons
The Abduction of 5 People in Vermont
Public Domain / Wikimedia Commons
The Abduction of 5 children
Public Domain / Wikimedia Commons
The Murder of Actress Elizabeth Short
Public Domain / Wikimedia Commons
The Murder of Benjamin "Bugsy" Siegel
Public Domain / Wikimedia Commons
The Murder of Barbara and Patricia Grimes
Public Domain / Wikimedia Commons
Jailbreak at Alcatraz Penitentiary
Public Domain / Wikimedia Commons
Death of TV personality Dorothy Kilgallen
Archive Photos / Archive Photos via Getty Images
Zodiac Serial killings
Public Domain / Wikimedia Commons
Hijacking of Northwest Orient Airlines
Public Domain / Wikimedia Commons
The Disappearance of Union Leader Jimmy Hoffa
Keystone / Hulton Archive via Getty Images
The Murder of Actor Bob Crane
Archive Photos / Archive Photos via Getty Images
Mass Murder of Eight People
Public Domain / Wikimedia Commons
Isabella Stewart Gardner Museum Heist
Public Domain / Wikimedia Commons
The Murder of Nicole Brown Simpson and Ronald Goldman
Archive Photos / Archive Photos via Getty Images
The Murder of Amber Hagerman
Alex Wong / Getty Images News via Getty Images
The Murder of Child Beauty Pageant Contestant JonBenét Ramsey
Barry Williams / Getty Images News via Getty Images
Mysterious Cold Cases That Have Baffled America for Decades
The Murder of Andrew and Abby Borden
The Villisca Ax Murders
The Abduction of 5 People in Vermont
The Disappearance of Judge Joseph F. Crater
The Abduction of 5 children
The Murder of Actress Elizabeth Short
The Murder of Benjamin "Bugsy" Siegel
The Murder of Barbara and Patricia Grimes
Jailbreak at Alcatraz Penitentiary
Death of TV personality Dorothy Kilgallen
Zodiac Serial killings
Hijacking of Northwest Orient Airlines
The Disappearance of Union Leader Jimmy Hoffa
The Murder of Actor Bob Crane
Mass Murder of Eight People
Tylenol Poisoning Incident of Seven People
Isabella Stewart Gardner Museum Heist
The Murder of Nicole Brown Simpson and Ronald Goldman
The Murder of Amber Hagerman
The Murder of Child Beauty Pageant Contestant JonBenét Ramsey
The Murder of Rapper Notorious B.I.G.

Mysterious Cold Cases That Have Baffled America for Decades

The American public is often captivated by crime. We watch programs like "Unsolved Mysteries" and "Law and Order," and there are even entire networks dedicated to all things crime, from Investigation Discovery (the ID channel) to the True Crime Network, and much more. Some cases are solved, although it may often take years. Others remain open. Many mysterious cold cases have baffled America for decades.

According to FBI statistics analyzed by theMurder Accountability Project, by 2023, 57.8 % of homicides were solved, a marked improvement from the previous year at 52.3 %. Yet, for that remaining percentage, there are still questions and no answers.

24/7 Tempo has compiled a list of mysterious cold cases that have baffled America for decades. We gathered information from the FBI, various media reports, and other sources, including regional publications. We concentrated on crimes that have remained unsolved for at least 15 years based on the latest available data.

This list is not exhaustive, and we used editorial discretion to identify the unsolved crimes that particularly captivated the public's interest and generated substantial media coverage. (Here is a list of the most famous major cases in FBI history.)

This post was updated on October 18, 2025 to clarify Borden's murder weapon, number of people that went missing in Vermont, what fire experts say about the Sodder children, origin of the nickname Black Dahlia, CBS's reporting on the Tylenol murders, details of the Ramsey murder, and date of Biggie Smalls murder.

Here are mysterious cold cases that have baffled America for decades:

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