12. The Life Aquatic with Steve Zissou (2004)
> Fellow leads: Owen Wilson, Anjelica Huston, Cate Blanchett
> Director: Wes Anderson
> Domestic box office: $24.01 million
In this comedic revenge story and homage to Jacques Cousteau, Murray plays oceanographer Steve Zissou, who is intent on destroying the shark that ate his diving partner.
11. St. Vincent (2014)
> Fellow leads: Melissa McCarthy, Naomi Watts, Jaeden Martell
> Director: Theodore Melfi
> Domestic box office: $44.14 million
In this comedy drama, Murray plays misanthrope Vincent MacKenna, whose dubious attempts at babysitting his 11-year-old neighbor develop into an unlikely friendship.
10. Broken Flowers (2005)
> Fellow leads: Jessica Lange, Sharon Stone, Julie Delpy
> Director: Jim Jarmusch
> Domestic box office: $13.75 million
In this French-American film, Murray portrays a rich retiree, Don Johnston, who wants nothing more than to live in peace. However, after receiving a mysterious letter, Don ends up on a quest to find out if he has a long-lost son.
9. What About Bob? (1991)
> Fellow leads: Richard Dreyfuss, Julie Hagerty, Charlie Korsmo
> Director: Frank Oz
> Domestic box office: $63.71 million
Murray stars in this comedy as Bob Wiley, a well-intentioned man with extreme phobias who follows his therapist on vacation and proceeds to drive him mad.
8. Caddyshack (1980)
> Fellow leads: Chevy Chase, Rodney Dangerfield, Ted Knight
> Director: Harold Ramis
> Domestic box office: $39.85 million
In one of his earliest big films, Murray plays Carl Spackler, a deranged groundskeeper at a country club who goes to extremes attempting to kill a gopher that has been damaging the golf course.