5. Sophie’s Choice (1982)
> Fellow leads: Kevin Kline, Peter MacNicol, Rita Karin
> Director: Alan J. Pakula
> Domestic box office: $30.04 million
In an Oscar-winning performance, Streep plays Sophie Zawistowska, a Polish immigrant living in Brooklyn who has a dark secret from the time she was interned in the Auschwitz concentration camp.
4. The Bridges of Madison County (1995)
> Fellow leads: Clint Eastwood, Annie Corley, Victor Slezak
> Director: Clint Eastwood
> Domestic box office: $71.52 million
Streep plays Francesca Johnson, a housewife in mid-1960s rural Iowa when a photographer shows up on her doorstep and causes her to rethink her life choices. She was nominated for an Academy Award and a SAG Award for this role.
3. Adaptation. (2002)
> Fellow leads: Nicolas Cage, Chris Cooper, Tilda Swinton
> Director: Spike Jonze
> Domestic box office: $22.50 million
In a performance that won her a Golden Globe Award, Streep portrays the journalist Susan Orlean in a comedy-drama about a writer’s struggles as he tries and fails to adapt Orlean’s book “The Orchid Thief” into a screenplay.
2. Kramer vs. Kramer (1979)
> Fellow leads: Dustin Hoffman, Jane Alexander, Justin Henry
> Director: Robert Benton
> Domestic box office: $106.26 million
In a performance that brought her first Academy Award, Streep plays Joanna Kramer, a woman who leaves her husband, a workaholic advertising executive played by Dustin Hoffman, and their young son only to return and pursue a fierce custody battle.
1. Fantastic Mr. Fox (2009)
> Fellow leads: George Clooney, Bill Murray, Jason Schwartzman
> Director: Wes Anderson
> Domestic box office: $21.00 million
Streep voices the role of Mrs. Fox in this animated comedy that finds Mr. Fox struggling to give up his life as a barnyard thief for safer pursuits.