19. Hope Springs (2012)
> Fellow leads: Tommy Lee Jones, Steve Carell, Jean Smart
> Director: David Frankel
> Domestic box office: $63.54 million
In this romantic comedy, Streep plays Kay Soames, who books herself and her husband into a weeklong marriage retreat as a way to reignite the spark. Their efforts fail to immediately catch fire. Streep received a Golden Globe Award nomination for this role.
18. A Series of Unfortunate Events (2004)
> Fellow leads: Jim Carrey, Jude Law, Liam Aiken
> Director: Brad Silberling
> Domestic box office: $118.63 million
In this black comedy based on the “Lemony Snicket” book series, Streep plays Aunt Josephine, who for a period of time has to care for two nieces and a nephew after their parents are killed in a fire. Since no good deed goes unpunished, she finds herself in her own dire straits.
17. August: Osage County (2013)
> Fellow leads: Dermot Mulroney, Julia Roberts, Juliette Lewis
> Director: John Wells
> Domestic box office: $37.74 million
In this American tragicomedy based on the 2007 Pulitzer Prize-winning play, Streep plays Violet Weston, a strong-willed Oklahoma woman who has oral cancer and is addicted to narcotics. Her sister and daughters gather around her after her husband, an alcoholic poet, disappears in a particularly hot August. Streep was nominated for an Academy Award, a Golden Globe Award and a BAFTA Award in this role.
16. The Manchurian Candidate (2004)
> Fellow leads:
> Director: Jonathan Demme
> Domestic box office: $65.95 million
In this psychological political thriller, a remake of the 1962 film, Streep plays Senator Eleanor Prentiss Shaw, a manipulative, ruthless woman who pushes her son into running for vice president. Streep received Golden Globe and BAFTA nominations for this role.